Desmin enters the nucleus of cardiac stem cells and modulates Nkx2.5 expression by participating in transcription factor complexes that interact with the nkx2.5 gene

The transcription factor Nkx2.5 and the intermediate filament protein desmin are simultaneously expressed in cardiac progenitor cells during commitment of primitive mesoderm to the cardiomyogenic lineage. Up-regulation of Nkx2.5 expression by desmin suggests that desmin may contribute to cardiogenic...

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Autors principals:	Christiane Fuchs, Sonja Gawlas, Philipp Heher, Sofia Nikouli, Hannah Paar, Mario Ivankovic, Martina Schultheis, Julia Klammer, Teresa Gottschamel, Yassemi Capetanaki, Georg Weitzer
Format:	Artigo
Idioma:	Inglês
Publicat:	The Company of Biologists 2016-02-01
Col·lecció:	Biology Open
Matèries:	Cardiac progenitor cells Desmin Nkx2.5 Nuclear localization Transcriptional regulation Intermediate filament protein
Accés en línia:	http://bio.biologists.org/content/5/2/140
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