Noradrenaline-trajectory phenotypes in septic shock: derivation and external validation in two independent cohorts

Abstract Background Septic shock is heterogeneous, and noradrenaline (NA) requirements evolve over time in ways that reflect vascular responsiveness and shock biology. Whether long-horizon NA dose-trajectory phenotypes are reproducible across healthcare systems and identifiable early in the clinical...

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Principais autores:	Gargi Yonatan, Amir Cohen, Dorit Stein, Ori Levi, Dor Cohen, Julia Klein, Hamutal S. Taube, Jacob Vine, Maxim Glebov, Teddy Lazebnik, Mor Saban, Yael Haviv, Eran Segal
Formato:	Artigo
Idioma:	Inglês
Publicado:	SpringerOpen 2026-06-01
Series:	Intensive Care Medicine Experimental
Assuntos:	Septic shock Phenotypes Noradrenaline trajectories Dynamic time warping
Acceso en liña:	https://doi.org/10.1186/s40635-026-00910-8
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