Fibrin-bound thrombin determines clot structure and blood thrombogenicity in normofibrinogenemia and dysfibrinogenemia

In thrombosis and haemostasis, coagulation and platelet activation pathways culminate to form solid fibrin clots, which can become vaso-occlusive or prevent excessive bleeding. We report a novel mechanism describing how developing fibrin clots prolong and modulate the reactivity of thrombin, an enz...

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Principais autores:	Siyu Sun, Mark Roest, Rolf T. Urbanus, Elena Campello, Sarah Beck, Cristiana Bulato, Simon D. Connell, Philip G. de Groot, Timea Feller, Dana Huskens, Joke Konings, Rita Marchi, Harmen Middelveld, Patricia Oftering, Bernhard Nieswandt, Alessandro Casini, Robert A.S. Ariens, Paolo Simioni, Johan W.M. Heemskerk, Bas de Laat
Formato:	Artigo
Idioma:	Inglês
Publicado:	Ferrata Storti Foundation 2026-02-01
Series:	Haematologica
Acceso en liña:	https://haematologica.org/article/view/13138
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