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Essential Role for Ethanolamine Plasmalogen Hydrolysis in Bacterial Lipopolysaccharide Priming of Macrophages for Enhanced Arachidonic Acid Release

Due to their high content in esterified arachidonic acid (AA), macrophages provide large amounts of eicosanoids during innate immune reactions. Bacterial lipopolysaccharide (LPS) is a poor trigger of AA mobilization in macrophages but does have the capacity to prime these cells for greatly increased...

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Principais autores: Luis Gil-de-Gómez, Alma M. Astudillo, Patricia Lebrero, María A. Balboa, Jesús Balsinde
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-09-01
coleção:Frontiers in Immunology
Assuntos:
lipolysaccharide priming
arachidonic acid
phospholipid remodeling
lipid mediators
eicosanoids
monocytes/macrophages
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01251/full
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