High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids

Induced Pluripotent Stem Cells (iPSCs) can be differentiated into epithelial organoids that recapitulate the relevant context for CFTR and enable testing of therapies targeting Cystic Fibrosis (CF)-causing mutant proteins. However, to date, CF-iPSC-derived organoids have only been used to study phar...

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Autori principali:	Sunny Xia, Zoltán Bozóky, Michelle Di Paola, Onofrio Laselva, Saumel Ahmadi, Jia Xin Jiang, Amy L. Pitstick, Chong Jiang, Daniela Rotin, Christopher N. Mayhew, Nicola L. Jones, Christine E. Bear
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2021-12-01
Serie:	Cells
Soggetti:	cystic fibrosis high throughput in vitro models CFTR ENaC ion channel activity
Accesso online:	https://www.mdpi.com/2073-4409/10/12/3419
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