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Mucosal tenofovir 1% gel stimulates cell proliferation and type I/III interferon pathways

ABSTRACT Oral tenofovir is a key antiretroviral used for treatment and pre-exposure prophylaxis (PrEP) of human immunodeficiency virus (HIV). A gel form has been tested for vaginal and rectal PrEP. We have shown that 7 days of tenofovir 1% gel had broad-ranging effects on gene expression in the rect...

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Auteurs principaux: Sean M. Hughes, Fernanda L. Calienes, Claire N. Levy, Urvashi Pandey, Germán G. Gornalusse, Ross D. Cranston, Javier R. Lama, Jim Pickett, Rhonda M. Brand, Craig W. Hendrix, Mark A. Marzinke, James Y. Dai, Bhavna Balar, Jessica E. Justman, Gonasagrie Nair, Alicia R. Berard, Kenzie Birse, Laura Noel-Romas, Kenneth H. Mayer, Joanne D. Stekler, Romel Mackelprang, Adam D. Burgener, Ian McGowan, Cheryl M. Cameron, Mark J. Cameron, Kim A. Woodrow, Florian Hladik
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2026-05-01
Collection:Microbiology Spectrum
Sujets:
microbicide
antiretroviral treatment
pre-exposure prophylaxis
tenofovir
HIV
Accès en ligne:https://journals.asm.org/doi/10.1128/spectrum.01680-25
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