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Favipiravir: the hidden threat of mutagenic action

The antiviral drug favipiravir (FVP), which is a structural analogue of guanosine, undergoes chemical transformation in infected cells by cellular enzymes into a nucleotide form — favipiravir ribose triphosphate (FVPRTP). FVP-RTP is able to bind to viral RNA-dependent RNA polymerase and integrate in...

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Principais autores: O. P. Zhirnov, A. I. Chernyshova
Format: Artigo
Sprog:Russo
Udgivet: Central Research Institute for Epidemiology 2021-05-01
Serier:Журнал микробиологии, эпидемиологии и иммунобиологии
Fag:
coronaviruses
favipiravir
chemotherapeutic targets
antivirals
mutagenesis
Online adgang:https://microbiol.elpub.ru/jour/article/view/1005
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