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Integration of metabolomics and machine learning revealed tryptophan metabolites are sensitive biomarkers of pemetrexed efficacy in non‐small cell lung cancer

Abstract Background Anti‐folate drug pemetrexed is a vital chemotherapy medication for non‐small cell lung cancer (NSCLC). Its response varies widely and often develops resistance to the treatment. Therefore, it is urgent to identify biomarkers and establish models for drug efficacy evaluation and p...

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Principais autores: Runbin Sun, Fei Fei, Min Wang, Junyi Jiang, Guangyu Yang, Na Yang, Dandan Jin, Zhi Xu, Bei Cao, Juan Li
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2023-09-01
coleção:Cancer Medicine
Assuntos:
drug resistance
machine learning
NSCLC
pemetrexed
pharmacometabolomics
Acesso em linha:https://doi.org/10.1002/cam4.6446
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