Highly variable timing renders immunotherapy efficacy and toxicity impractical biomarkers of one another in clinical practice

BackgroundA useful clinical biomarker requires not only association but also a consistent temporal relationship. For instance, chemotherapy-induced neutropenia and epidermal growth-factor inhibitor-related acneiform rash both occur within weeks of treatment initiation, thereby providing information...

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Bibliografiske detaljer

Principais autores:	Mitchell S. von Itzstein, Yuqiu Yang, Yiqing Wang, David Hsiehchen, Thomas Y. Sheffield, Farjana Fattah, Vinita Popat, Murtaza Ahmed, Jade Homsi, Jonathan E. Dowell, Sawsan Rashdan, Jay Lohrey, Hans J. Hammers, Randall S. Hughes, Tao Wang, Yang Xie, David E. Gerber
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2024-04-01
Serier:	Frontiers in Immunology
Fag:	efficacy immune checkpoint inhibitor (ICI) immune-related adverse event (irAE) immunotherapy monitoring toxicity
Online adgang:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1351739/full
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