Exo-miR-1290-induced by COX-2 overexpression promotes cancer-associated fibroblasts activation and tumor progression by CUL3-Nrf2 pathway in lung adenocarcinoma

Abstract Background Cancer-associated fibroblasts (CAFs) are critically involved in tumor progression by maintaining extracellular mesenchyma (ECM) production and improving tumor development. Cyclooxygenase-2 (COX-2) has been proved to promote ECM formation and tumor progression. However, the mechan...

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Hlavní autoři:	Xiaoming Bai, Jiaofang Shao, Tinghong Duan, Xue Liu, Min Wang, Xuanya Li, Qiang You, Zhiyuan Zhang, Jinshun Pan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-09-01
Edice:	Cell Communication and Signaling
Témata:	COX-2 Exo-miR-1290 CUL3 Nrf2 CAFs activation LUAD
On-line přístup:	https://doi.org/10.1186/s12964-023-01268-0
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