Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia

DYT1 dystonia is an inherited disease linked to mutation in the TOR1A gene encoding for the protein torsinA. Although the mechanism by which this genetic alteration leads to dystonia is unclear, multiple lines of clinical evidence suggest a link between dystonia and a reduced dopamine D2 receptor (D...

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Bibliografiset tiedot

Päätekijät:	Francesco Napolitano, Massimo Pasqualetti, Alessandro Usiello, Emanuela Santini, Giulia Pacini, Giuseppe Sciamanna, Francesco Errico, Annalisa Tassone, Valeria Di Dato, Giuseppina Martella, Dario Cuomo, Gilberto Fisone, Giorgio Bernardi, Georgia Mandolesi, Nicola B. Mercuri, David G. Standaert, Antonio Pisani
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2010-06-01
Sarja:	Neurobiology of Disease
Aiheet:	Dystonia D2 dopamine receptor Adenosine
Linkit:	http://www.sciencedirect.com/science/article/pii/S0969996110000641
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