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Spirocyclopiperazinium salt compound DXL-A-24 improves visceral sensation and gut microbiota in a rat model of irritable bowel syndrome

Irritable bowel syndrome (IBS) is characterized by visceral pain, impaired intestinal barrier and a disorder of the microbiota. DXL-A-24 has analgesic and anti-inflammatory effects by inhibiting neuropeptides and inflammatory factors. In this study, we used chronic unpredictable mild stress (CUMS) i...

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Principais autores: Yan Xu, Ru Yao, Wenxue Zhao, Jianguo Zhu, Jingchun Yao, Guimin Zhang, Dongguang Liu
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2023-06-01
סדרה:Heliyon
נושאים:
Irritable bowel syndrome
Microbiota
Visceral hypersensitivity
Gut barrier
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2405844023037519
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