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Genomic and spatial analysis of local recurrences following risk-adapted breast radiotherapy in the IMPORT trials

Abstract Background Ipsilateral breast tumour recurrences (IBTR) that occur after breast-conserving surgery (BCS) and breast radiotherapy may be ‘true recurrences’ or independent ‘new primaries’. Contralateral breast cancers (CBC) are usually assumed to be new primary tumours. Understanding the patt...

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Príomhchruthaitheoirí: Sara V. Lightowlers, Maria Roman-Escorza, Ceilidh Welsh, Judith M. Bliss, Jason S. Carroll, H. Y. Charlie Chan, Karl Harrison, Joanne S. Haviland, Nuala Healy, Monica L. Jefford, Rajesh Jena, Anna M. Kirby, Cliona C. Kirwan, Elena Provenzano, Mark A. Sydenham, Isabel Syndikus, James Tanner, Ramona Woitek, Charlotte E. Coles, Elinor J. Sawyer
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: BMC 2026-04-01
Sraith:Breast Cancer Research
Ábhair:
Breast cancer
Breast radiotherapy
Risk-adapted radiotherapy
Local recurrence
Tumour evolution
Rochtain ar líne:https://doi.org/10.1186/s13058-026-02232-9
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