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Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues

Abstract Despite their importance in determining protein abundance, a comprehensive catalogue of sequence features controlling protein‐to‐mRNA (PTR) ratios and a quantification of their effects are still lacking. Here, we quantified PTR ratios for 11,575 proteins across 29 human tissues using matche...

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Principais autores: Basak Eraslan, Dongxue Wang, Mirjana Gusic, Holger Prokisch, Björn M Hallström, Mathias Uhlén, Anna Asplund, Frederik Pontén, Thomas Wieland, Thomas Hopf, Hannes Hahne, Bernhard Kuster, Julien Gagneur
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Nature 2019-02-01
coleção:Molecular Systems Biology
Assuntos:
codon usage
mRNA sequence motifs
proteomics
transcriptomics
translational control
Acesso em linha:https://doi.org/10.15252/msb.20188513
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