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Structural investigations on the mitochondrial uncouplers niclosamide and FCCP

There has been renewed interest in using mitochondrial uncoupler compounds such as niclosamide and carbonyl cyanide p‐(trifluoromethoxy)phenylhydrazone (FCCP) for the treatment of obesity, hepatosteatosis and diseases where oxidative stress plays a role. However, both FCCP and niclosamide have undes...

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Autori principali: Mei Ying Ng, Zhi Jian Song, Choon Hong Tan, Marcella Bassetto, Thilo Hagen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2024-07-01
Serie:FEBS Open Bio
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Accesso online:https://doi.org/10.1002/2211-5463.13817
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