Computer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer

Platelet-derived growth factor alpha (PDGFRA) plays a significant role in various malignant tumors. PDGFRA expression boosts thyroid cancer cell proliferation and metastasis. Radiorefractory thyroid cancer is poorly differentiated, very aggressive, and resistant to radioiodine therapy. Thus, novel a...

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Principais autores:	Hira Khalid, Farah Sattar, Iqra Ahmad, Valdir Ferreira de Paula Junior, Umar Nishan, Riaz Ullah, Hanna Dib, Khaled W. Omari, Mohibullah Shah
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-01-01
Colecção:	Frontiers in Pharmacology
Assuntos:	anticancer natural products drug design ethnopharmacology virtual screening
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1512864/full
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