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Estrogen Receptor β1 Expression Patterns Have Different Effects on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors’ Treatment Response in Epidermal Growth Factor Receptor Mutant Lung Adenocarcinoma

Estrogen receptor β (ERβ) can regulate cellular signaling through non-genomic mechanisms, potentially promoting resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, the mechanisms underlying the ERβ-mediated resistance to EGFR TKIs remain poorly understoo...

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Principais autores: Lijuan Zhang, Meng Tian, Jiamao Lin, Jianbo Zhang, Haiyong Wang, Zhenxiang Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-01-01
coleção:Frontiers in Oncology
Assuntos:
estrogen receptor β
lung adenocarcinoma
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs)
non-genomic mechanism
resistance
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2020.603883/full
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