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T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson’s disease

Abstract A role of the immune system in Parkinson’s disease (PD) progression has long been suspected due to the increased frequency of activated glial cells and infiltrating T cells in the substantia nigra. It was previously reported that PD donors have increased T cell responses towards PINK1 and α...

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Autori principali: Emil Johansson, Antoine Freuchet, Gregory P. Williams, Tanner Michealis, April Frazier, Irene Litvan, Jennifer G. Goldman, Roy N. Alcalay, David G. Standaert, Amy W. Amara, Natividad Stover, Edward A. Fon, Ronald B. Postuma, John Sidney, David Sulzer, Cecilia S. Lindestam Arlehamn, Alessandro Sette
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-05-01
Serie:npj Parkinson's Disease
Accesso online:https://doi.org/10.1038/s41531-025-01001-3
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