Identifying potential inhibitors of phosphatidylinositol 4,5-bisphosphate 3-kinase: Molecular dynamic insights into the interaction and inhibitory mechanism

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) plays a crucial role in signaling pathways and has emerged as an attractive target for anticancer therapy. Developing small-molecule inhibitors targeting PIK3CA has emerged as a promising therapeutic strategy. Here, we e...

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Detalhes bibliográficos

Principais autores:	Taj Mohammad, Afzal Hussain, Mohamed F. Alajmi, Saba Hasan, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-06-01
coleção:	Chemical Physics Impact
Assuntos:	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha Phytoconstituents Apollinine Isoglycyrol Virtual screening
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2667022424000021
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