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The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology

The fragile X mental retardation protein (FMRP), an RNA-binding protein that mediates the transport, stability, and translation of hundreds of brain RNAs, is critically involved in regulating synaptic function. Loss of FMRP, as in fragile X syndrome (FXS), is a leading monogenic cause of autism and...

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Principais autores: Jessica L. Huebschman, Kitzia S. Corona, Yuhong Guo, Laura N. Smith
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-09-01
Serier:Frontiers in Molecular Neuroscience
Fag:
striatum
dendritic spine
RNA-binding proteins
FXS
synapse structure
morphology
Online adgang:https://www.frontiersin.org/article/10.3389/fnmol.2020.00161/full
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