Adaptation to Fluconazole via Aneuploidy Enables Cross-Adaptation to Amphotericin B and Flucytosine in Cryptococcus neoformans

ABSTRACT The high morbidity and mortality of cryptococcal meningitis is due to the limited range of therapeutic options: only three classes of antifungal drugs are available (polyenes [amphotericin B], azoles [fluconazole], and pyrimidine analogues [flucytosine]). Fluconazole is the most widely used...

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Principais autores:	Feng Yang, Vladimir Gritsenko, Hui Lu, Cheng Zhen, Lu Gao, Judith Berman, Yuan-ying Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2021-10-01
coleção:	Microbiology Spectrum
Assuntos:	amphotericin B aneuploidy cross-adaptation Cryptococcus neoformans fluconazole flucytosine
Acesso em linha:	https://journals.asm.org/doi/10.1128/Spectrum.00723-21
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