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Genome Editing With TALEN, CRISPR-Cas9 and CRISPR-Cas12a in Combination With AAV6 Homology Donor Restores T Cell Function for XLP

X-linked lymphoproliferative disease is a rare inherited immune disorder, caused by mutations or deletions in the SH2D1A gene that encodes an intracellular adapter protein SAP (Slam-associated protein). SAP is essential for mediating several key immune processes and the immune system - T cells in pa...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Benjamin C. Houghton, Neelam Panchal, Simone A. Haas, Kay O. Chmielewski, Markus Hildenbeutel, Thomas Whittaker, Claudio Mussolino, Toni Cathomen, Adrian J Thrasher, Claire Booth
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2022-05-01
Rangatū:Frontiers in Genome Editing
Ngā marau:
TALEN
CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 (CRISPR associated protein 9)-mediated genome editing
Cas12a
X-linked lymphoproliferative disease (XLP)
primary immunodefciencies
AAV6
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fgeed.2022.828489/full
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