NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis

Cancer associated fibroblasts (CAFs) are known to promote pro-tumorigenic inflammation. Here, the authors show that CAFs sense tissue damage and activate NLRP3 inflammasome and pro-inflammatory IL-1β secretion, and CAF-derived inflammasome signalling promotes breast tumour growth and metastasis.

Detalles Bibliográficos

Principais autores:	Nour Ershaid, Yoray Sharon, Hila Doron, Yael Raz, Ophir Shani, Noam Cohen, Lea Monteran, Leonor Leider-Trejo, Amir Ben-Shmuel, Muhammad Yassin, Motti Gerlic, Adit Ben-Baruch, Metsada Pasmanik-Chor, Roni Apte, Neta Erez
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2019-09-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-019-12370-8
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