Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the <i>Mecp2-</i>Deficient Mouse Model

Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by mutations in the MeCP2 gene, predominantly affecting females. Recent work with MeCP2-deficient mouse models showed a significant role in glutamatergic transmission, specifically microglia-produced glutamate and glutaminase upregul...

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Detalhes bibliográficos

Principais autores:	Preeti Vyas, Elizabeth Smith Khoury, Nirnath Sah, Anjali Sharma, Javier Allende Labastida, Elizabeth L. Wilkinson, Kathleen Lac, Nerketa N. L. Damiba, Amanda Fowler, Jinhuan Liu, Ashley Bedner, Pavel Majer, Tomás Tichý, Ajit G. Thomas, Rana Rais, Barbara S. Slusher, Rangaramanujam M. Kannan, Sujatha Kannan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-02-01
coleção:	Cells
Assuntos:	Rett Syndrome glutaminergic pathway D-TTM020 dendrimer nanotherapy nanomedicine
Acesso em linha:	https://www.mdpi.com/2073-4409/15/3/272
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