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Development of targeted therapy therapeutics to sensitize triple-negative breast cancer chemosensitivity utilizing bacteriophage phi29 derived packaging RNA

Abstract Background To date, triple-negative breast cancer (TNBC) treatment options are limited because of the loss of target receptors and, as a result, are only managed with chemotherapy. What is worse is that TNBC is frequently developing resistance to chemotherapy. By using small interfering RNA...

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Hlavní autoři: Long Zhang, Chaofeng Mu, Tinghong Zhang, Dejun Yang, Chenou Wang, Qiong Chen, Lin Tang, Luhui Fan, Cong Liu, Jianliang Shen, Huaqiong Li
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2021-01-01
Edice:Journal of Nanobiotechnology
Témata:
RNA nanoparticles
XBP1
siRNA
TNBC
Chemoresistance
On-line přístup:https://doi.org/10.1186/s12951-020-00758-4
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