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Hydrogel microspheres loaded with sinomenine and Drynaria rhizome enhance the treatment of rheumatoid arthritis via immune regulation and promoting bone repair

Abstract Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovial inflammation, cartilage destruction, and bone loss. Current therapeutic approaches are often limited by short drug half-life, insufficient local drug release, and substantial systemic side effects.In this s...

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Principais autores: Li Cai, Jian Gao, Kai Zhang, Bing Xiao, SiJia Xu, Wei Zhao, Juan Li, Yanli Zhou, WenYing Zhu, ShuYuan Liu, TingTing Pei, JunHua Li, Yang Chen, ShiXian Chen, Ji Li
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-01-01
coleção:Journal of Nanobiotechnology
Assuntos:
Rheumatoid arthritis
Hydrogel
Immunoregulation
Inflammation
Bone repair
Drug delivery
Acesso em linha:https://doi.org/10.1186/s12951-026-04063-4
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