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A universally applicable toolbox for single-molecule quantification of chimeric antigen receptors using linker-resolved dSTORM microscopy

Chimeric antigen receptor (CAR)-T cell therapies targeting CD19 have demonstrated remarkable clinical efficacy in B-cell malignancies. However, substantial differences exist in therapeutic outcomes, partly due to differences in CAR design and surface expression. Current methods for CAR detection, in...

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Principais autores: Josefine Michael, Peter Spieler, Fabio Toppeta, Leon Gehrke, Nicole Seifert, Björn Grams, Rick Seifert, Hermann Einsele, Michael Hudecek, Markus Sauer, Thomas Nerreter
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-07-01
Serier:Frontiers in Immunology
Fag:
anti-CD19
CAR-T cell therapy
chimeric antigen receptor
dSTORM
microscopy
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1897225/full
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