Comprehensive biomarker and modeling approach to support dose finding for BI 836880, a VEGF/Ang-2 inhibitor

Abstract Background BI 836880 is a humanized bispecific nanobody® that binds to and blocks vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2). A comprehensive biomarker and modeling approach is presented here that supported dose finding for BI 836880. Methods Two Phase I dose-escal...

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Autors principals:	Sascha Keller, Ulrich Kunz, Ulrike Schmid, Jack Beusmans, Martin Büchert, Min He, Girish Jayadeva, Christophe Le Tourneau, Doreen Luedtke, Heiko G. Niessen, Zohra Oum’hamed, Sina Pleiner, Xiaoning Wang, Ralph Graeser
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2024-10-01
Col·lecció:	Journal of Translational Medicine
Matèries:	BI 836880 Biomarkers VEGF Ang-2 Pharmacokinetics Pharmacodynamics
Accés en línia:	https://doi.org/10.1186/s12967-024-05612-x
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