Discovery of a small molecule TLR3 agonist adjuvant

Abstract Pattern-recognition receptor (PRR) agonists are valuable agents across multiple medical applications, from vaccinology to immune-oncology. However, well-defined and potent small molecule agonists for many PRRs still await discovery and development. Screening of chemical libraries of ~200,00...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Branden Lee, Danica Dong, Etsuro Nanishi, John Mark Awad, Kimia Z. Abedi, Yoshine Saito, Francesco Borriello, Soumik Barman, Byron Brook, Aisling Kelly, Manisha Menon, Constance Marques-Mourlet, Maansi V. Gupta, Ida Lister, Chiwoo Oh, Kevin Lyskawa, Morgan Goetz, Kristina Walker, Wing Ki Cheng, Spencer E. Brightman, Pankaj Sharma, Timothy R. O’Meara, Katherine Chew, Daniel Vieira, Kevin Ryff, Cali Sweitzer, Sanya Thomas, Simon D. van Haren, Matthew Pettengill, Hyuk-Soo Seo, Sirano Dhe-Paganon, Wei Zhang, Ofer Levy, David J. Dowling
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Nature Portfolio 2025-12-01
سلاسل:	Nature Communications
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41467-025-66878-3
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!