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Identification of the D-glucuronyl C5-epimerase that introduces iduronic acid into N-linked glycans decorating archaeal glycoproteins

Abstract In Halobacterium salinarum, halophilic archaea that grow in saturated salt solutions, glycoproteins are modified by an N-linked tetrasaccharide that includes iduronic acid (IdoA). This represents the only known example of IdoA, a sugar better known as a component of glycosaminoglycans found...

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Principais autores: Zlata Vershinin, Marianna Zaretsky, Anna Notaro, Dandan Yu, Antonio Molinaro, Shahar Sofer, Iris Grossman-Haham, Cristina De Castro, Jerry Eichler
格式: Artigo
语言:Inglês
出版: Nature Portfolio 2025-11-01
丛编:Communications Biology
在线阅读:https://doi.org/10.1038/s42003-025-08987-9
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