The effect of cardioplegic supplementation with sildenafil on cardiac energetics in a piglet model of cardiopulmonary bypass and cardioplegic arrest with warm or cold cardioplegia

Cardioplegic cardioprotection strategies used during paediatric open-heart surgery remain suboptimal. Sildenafil, a phosphodiesterase 5 (PDE-5) inhibitor, has been shown to be cardioprotective against ischemia/reperfusion injury in a variety of experimental models and this study therefore tested the...

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Autores principales:	Katie L. Skeffington, Eltayeb Mohamed Ahmed, Filippo Rapetto, Guillaume Chanoit, Andrew R. Bond, Antonella Vardeu, Mohamed T. Ghorbel, M-Saadeh Suleiman, Massimo Caputo
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2023-06-01
Colección:	Frontiers in Cardiovascular Medicine
Materias:	cardiac surgery cardioprotection ischaemia and reperfusion injury congenital heart disease sildenafil cardiopulmonary bypass
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fcvm.2023.1194645/full
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