Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signaling

Recurrent missense mutations of the PIK3CA oncogene are among the most frequent drivers of human cancers. These often lead to constitutive activation of its product p110α, a phosphatidylinositol 3-kinase (PI3K) catalytic subunit. In addition to causing a broad range of cancers, the H1047R mutation i...

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Principais autores:	Elise Marechal, Anne Poliard, Kilian Henry, Mathias Moreno, Mathilde Legrix, Nicolas Macagno, Grégoire Mondielli, Teddy Fauquier, Anne Barlier, Heather C. Etchevers
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-10-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	neural crest embryo PI3K cancer birth defect cleft palate
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2022.1013001/full
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