Molecular basis and cellular effects of Janus-class–driven cytoplasmic PYK2 coacervates

Abstract Kinase activity is increasingly linked to biomolecular phase separation. Focal adhesion kinase (FAK) forms membrane-associated condensates with paxillin to promote adhesion. Here we show that its paralogue, proline-rich tyrosine kinase 2 (PYK2), undergoes phase separation via a distinct mec...

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Autors principals:	Giovanni Colombo, Israa Salem, Kacper Szczepski, Piao Yu, Shaden Alfaiyz, Francisco Javier Guzmán-Vega, Ahmed Abogosh, Maxat Kulmanov, Samah Al-Harthi, Gress Kadaré, Robert Hoehndorf, Jean-Antoine Girault, Łukasz Jaremko, Afaque A. Momin, Stefan T. Arold
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-01-01
Col·lecció:	Communications Biology
Accés en línia:	https://doi.org/10.1038/s42003-025-09463-0
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