Transplantation of hiPSC-derived pericytes rescues Alzheimer’s disease phenotypes in APOE4/4 mice through IGF2-rich apoptotic vesicles

Abstract Background Effective therapies for Alzheimer’s disease (AD) remain to be developed. APOE4 is the strongest genetic risk factor for late-onset AD. Pericyte degeneration and blood–brain barrier (BBB) disruption are thought to be early biomarkers of AD and contribute to cognitive decline in AP...

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Detalhes bibliográficos
Main Authors: Chuanfeng Xiong, Yao Tang, Junhua Chen, Mingming Fan, Lan Wei, Zhaoran Dong, Xingqiang Lai, Xuejiao Men, Qiumin Chen, Dairui Li, Wenjin Ye, Yuanchen Ma, Xiaoyong Chen, Weijun Huang, Zhengqi Lu, Hong Chen, Yunfeng Shen, Yanming Chen, Andy Peng Xiang, Weiqiang Li
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-11-01
Colecção:Translational Neurodegeneration
Assuntos:
Alzheimer’s disease
APOE4
Pericytes
ApoVs
IGF2
Acesso em linha:https://doi.org/10.1186/s40035-025-00512-6
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