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Microglial Pten safeguards postnatal integrity of the cortex and sociability

Microglial abnormalities may contribute to neurodevelopmental disorders. PTEN is implicated as a susceptibility gene for autism spectrum disorders and its germline ablation in mice causes behavioral abnormalities. Here we find postnatal PTEN deletion in microglia causes deficits in sociability and n...

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Principais autores: Xing Zhou, Jiacheng Wei, Liang Li, Zhenfeng Shu, Ling You, Yang Liu, Ruozhu Zhao, Jiacheng Yao, Jianbin Wang, Minmin Luo, Yousheng Shu, Kexin Yuan, Hai Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-12-01
coleção:Frontiers in Immunology
Assuntos:
microglia
PTEN
phagocytosis
VGLUT1
autism spectrum disorders
cerebral cortex
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1059364/full
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