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Structural Comparison of Diverse HIV-1 Subtypes using Molecular Modelling and Docking Analyses of Integrase Inhibitors

The process of viral integration into the host genome is an essential step of the HIV-1 life cycle. The viral integrase (IN) enzyme catalyzes integration. IN is an ideal therapeutic enzyme targeted by several drugs; raltegravir (RAL), elvitegravir (EVG), dolutegravir (DTG), and bictegravir (BIC) hav...

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Auteurs principaux: Darren Isaacs, Sello Given Mikasi, Adetayo Emmanuel Obasa, George Mondinde Ikomey, Sergey Shityakov, Ruben Cloete, Graeme Brendon Jacobs
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2020-08-01
Collection:Viruses
Sujets:
integrase
naturally occurring polymorphisms
HIV-1
molecular modelling
molecular docking
diversity
Accès en ligne:https://www.mdpi.com/1999-4915/12/9/936
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