Structural Insights into the Marine Alkaloid Discorhabdin G as a Scaffold towards New Acetylcholinesterase Inhibitors

In this study, Antarctic <i>Latrunculia</i> sponge-derived discorhabdin G was considered a hit for developing potential lead compounds acting as cholinesterase inhibitors. The hypothesis on the pharmacophore moiety suggested through molecular docking allowed us to simplify the structure of the metab...

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Detalhes bibliográficos

Principais autores:	Andrea Defant, Giacomo Carloni, Nicole Innocenti, Tomaž Trobec, Robert Frangež, Kristina Sepčić, Ines Mancini
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-04-01
coleção:	Marine Drugs
Assuntos:	marine metabolite drug design organic synthesis molecular docking ADME prediction acetylcholinesterase inhibition
Acesso em linha:	https://www.mdpi.com/1660-3397/22/4/173
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