Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses

Abstract Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a candidate malaria vaccine antigen expressed on merozoites and sporozoites. PfAMA1’s polymorphic nature impacts vaccine-induced protection. To address polymorphism, three Diversity Covering (DiCo) protein sequences were designed a...

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Bibliografske podrobnosti

Principais autores:	Edmond J. Remarque, Bart W. Faber, Roberto Rodriguez Garcia, Herman Oostermeijer, Sodiomon B. Sirima, Issa Nebie Ouedraogo, Leila Kara, Odile Launay, Sophie Houard, Odile Leroy, Clemens H. M. Kocken
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2021-04-01
Serija:	npj Vaccines
Online dostop:	https://doi.org/10.1038/s41541-021-00319-2
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