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Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells

<p>Abstract</p> <p>Background</p> <p>The type-II-cytokine IFN-γ is a pivotal player in innate immune responses but also assumes functions in controlling tumor cell growth by orchestrating cellular responses against neoplastic cells. The role of IFN-γ in melanoma is not fully understood: it is a well...

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Principais autores: Schmitt Martina J, Philippidou Demetra, Reinsbach Susanne E, Margue Christiane, Wienecke-Baldacchino Anke, Nashan Dorothee, Behrmann Iris, Kreis Stephanie
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-12-01
coleção:Cell Communication and Signaling
Assuntos:
IFN-γ
Jak/STAT pathway
STAT1
Signaling
Melanoma
miR-29
Tumor-suppressor
Acesso em linha:http://www.biosignaling.com/content/10/1/41
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