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Ganglioside GM3 in the Tumor Microenvironment: Mechanisms of Signaling Regulation and Strategies for Angiogenesis Inhibition

Ganglioside GM3, a fundamental glycosphingolipid on the mammalian cell surface, is a key regulator of transmembrane signaling and cellular recognition. In oncology, GM3 acts as a tumor suppressor by modulating the activity of various receptor tyrosine kinases (RTKs) and their downstream pathways. Re...

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Gardado en:
Principais autores: Min Zeng, Hongda Zhuang, Siyuan Zhao, Roger Chammas, Yong Chen
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2026-03-01
Series:Biomolecules
Assuntos:
ganglioside GM3
tumor angiogenesis
VEGF signaling
tumor microenvironment
targeted therapy
HIF-1α
Acceso en liña:https://www.mdpi.com/2218-273X/16/3/464
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