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C-peptide promotes myogenic differentiation in vitro and low serum levels are associated with sarcopenia in adults and the elderly

Abstract Background Sarcopenia, the age-related loss of muscle mass and function, is a growing public health problem. Its multifactorial causes including poor nutrition, physical inactivity, and underlying diseases. Research suggests a role for C-peptide in muscle regulation, but its link to sarcope...

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Principais autores: Yvelise Ferro, Alberto Castagna, Samantha Maurotti, Francesca Rita Noto, Elisa Mazza, Valeria Rizzo, Carmelo Pujia, Angelo Galluccio, Angela Sciacqua, Carmine Gazzaruso, Stefano Romeo, Arturo Pujia, Tiziana Montalcini
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2026-03-01
Series:Journal of Translational Medicine
Assuntos:
Sarcopenia
Myogenic differentiation
C-peptide
Muscle atrophy
Fractures
Appendicular skeletal muscle mass
Acceso en liña:https://doi.org/10.1186/s12967-026-07983-9
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