The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.

A major target of the HPV E6 oncoprotein is the human Discs Large (hDlg) tumour suppressor, although how this interaction contributes to HPV-induced malignancy is still unclear. Using a proteomic approach we show that a strong interacting partner of hDlg is the RhoG-specific guanine nucleotide excha...

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Autors principals:	Vanitha Krishna Subbaiah, Paola Massimi, Siaw Shi Boon, Michael P Myers, Lisa Sharek, Rafael Garcia-Mata, Lawrence Banks
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2012-02-01
Col·lecció:	PLoS Pathogens
Accés en línia:	http://europepmc.org/articles/PMC3285591?pdf=render
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