Development and multicenter external validation of an intratumoral and peritumoral ultrasound-based radiomics model for preoperative prediction of HER2 status in IHC 2 + breast cancer

Abstract Background Accurate assessment of human epidermal growth factor receptor 2 (HER2) status can guide eligibility for HER2-targeted therapy in breast cancer. We aimed to develop and externally validate a nomogram that combines ultrasound (US) radiomics features from intratumoral and peritumora...

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Hauptverfasser:	Jingbo Wang, Nina Qu, Can Liu, Yayun Lin, Yan Cui, Xiaoli Cao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-12-01
Schriftenreihe:	European Journal of Medical Research
Schlagworte:	Breast cancer HER2 status Radiomics Peritumoral ultrasound segmentation Nomogram Ultrasound
Online-Zugang:	https://doi.org/10.1186/s40001-025-03698-7
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