Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics

Spectinamides 1599 and 1810 are lead spectinamide compounds currently under preclinical development to treat multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. These compounds have previously been tested at various combinations of dose level, dosing frequency, and route of...

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Huvudupphov:	Keyur R. Parmar, Pradeep B. Lukka, Santosh Wagh, Zaid H. Temrikar, Jiuyu Liu, Richard E. Lee, Miriam Braunstein, Anthony J. Hickey, Gregory T. Robertson, Mercedes Gonzalez-Juarrero, Andrea Edginton, Bernd Meibohm
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	MDPI AG 2023-06-01
Serie:	Pharmaceutics
Ämnen:	mPBPK spectinamides intratracheal PBPK subcutaneous PBPK interspecies extrapolation granuloma model
Länkar:	https://www.mdpi.com/1999-4923/15/6/1759
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