Selective Inhibitor of Protein Kinase PKN3 Generated by Conjugation of a Structurally Optimized Bumped <i>N</i>-(2-Aminoethyl)-8-anilinoisoquinoline-5-sulfonamide (H-9) with <span style="font-variant: small-caps">d</span>-Arginine-Rich Chain

The protein kinase N family belongs to the AGC kinase group and contains three isozymes: PKN1, PKN2, and PKN3. Catalytic domains of PKNs share high sequence similarity, yet the proteins differ in tissue distribution, functions, and involvement in pathological processes. In particular, PKN3 has been...

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Autores principales:	Varvara Smorodina, Eva Lea Jääger, Tanel Sõrmus, Ernesto De Jesus Zapata Flores, Erki Enkvist, Asko Uri, Kaido Viht
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2026-02-01
Colección:	Molecules
Materias:	protein kinase PKN3 selective inhibitor gatekeeper residue
Acceso en línea:	https://www.mdpi.com/1420-3049/31/4/585
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