Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity

ABSTRACT Antifungal tolerance can promote the emergence of resistance yet often incurs fitness costs for fungal pathogens. How tolerant populations compensate for these deficits and how they may be therapeutically targeted remain poorly understood. Here, we investigate four sequential Candida paraps...

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Autori principali:	Farnaz Daneshnia, Liuyang Cai, Deepika Gunasekaran, Isha Gautam, Austin M. Perry, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Julieta Munoz, Dorian Padilla, Süleyha Hilmioglu-Polat, Shenglin Mei, Daniel J. Floyd, Miquel Àngel Schikora-Tamarit, Diego Fuentes, Maria Artigues-Lleixà, Louise A. Walker, Samuel M. Gonçalves, Mostafa Salehi, Agostinho Carvalho, Jigar V. Desai, David S. Perlin, Carol A. Munro, Alex Hopke, Tuo Wang, Toni Gabaldón, Wenjie Fang, Clarissa J. Nobile, Michael K. Mansour, Amir Arastehfar
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2026-04-01
Serie:	Microbiology Spectrum
Soggetti:	echinocandins polyenes macrophage polarization biofilms cell wall remodeling resistance
Accesso online:	https://journals.asm.org/doi/10.1128/spectrum.03043-25
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