Transcriptional and Post-Transcriptional Polar Effects in Bacterial Gene Deletion Libraries

ABSTRACT Single-gene deletions can affect the expression levels of other genes in the same operon in bacterial genomes. Here, we used proteomics for 133 Escherichia coli gene deletion mutants and transcriptome sequencing (RNA-seq) data from 71 mutants to probe the extent of transcriptional and post-...

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Autors principals:	André Mateus, Malay Shah, Johannes Hevler, Nils Kurzawa, Jacob Bobonis, Athanasios Typas, Mikhail M. Savitski
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2021-10-01
Col·lecció:	mSystems
Matèries:	Keio collection knockout polar effects proteomics single gene deletion
Accés en línia:	https://journals.asm.org/doi/10.1128/msystems.00813-21
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