Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth

The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse genetic model to activate platelet derived growth factor receptor-alpha (PDGFRα) specifically in the st...

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Detalhes bibliográficos

Principais autores:	Anisha M. Hammer, Gina M. Sizemore, Vasudha C. Shukla, Alex Avendano, Steven T. Sizemore, Jonathan J. Chang, Raleigh D. Kladney, Maria C. Cuitiño, Katie A. Thies, Quinn Verfurth, Arnab Chakravarti, Lisa D. Yee, Gustavo Leone, Jonathan W. Song, Samir N. Ghadiali, Michael C. Ostrowski
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-06-01
coleção:	Neoplasia: An International Journal for Oncology Research
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S1476558617301392
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