Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells

A series of 3,5-bis(benzylidene)-1-dichloroacetyl-4-piperidones <b>1a</b>–<b>l</b> was evaluated against Ca9-22, HSC-2, HSC-3, and HSC-4 squamous cell carcinomas. Virtually all of the compounds displayed potent cytotoxicity, with 83% of the CC₅₀ values being submicromolar and several CC<s...

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Principais autores:	Mohammad Hossain, Praveen K. Roayapalley, Hiroshi Sakagami, Keitaro Satoh, Kenjiro Bandow, Umashankar Das, Jonathan R. Dimmock
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2022-06-01
Serija:	Medicines
Teme:	unsaturated ketones cytotoxicity dichloroacetic acid tumor-selective toxicity structure-activity relationships
Online dostop:	https://www.mdpi.com/2305-6320/9/6/35
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