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Genetics-guided therapy in neuroendocrine carcinoma: response to BRAF- and MEK-inhibitors

Background: Metastatic neuroendocrine carcinoma (NEC) is associated with short survival. Other than platinum-based chemotherapy, there is no clear standard regimen. Current guidelines suggest that combination treatment with BRAF-inhibitors should be considered for patients with BRAF V600E-mutated NE...

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Principais autores: Lovisa Falkman, Anders Sundin, Britt Skogseid, Johan Botling, Yvette Bernardo, Göran Wallin, Liang Zhang, Staffan Welin, Ieva Lase, Kazhan Mollazadegan, Joakim Crona
Formato: Artigo
Idioma:Inglês
Publicado em: Upsala Medical Society 2024-04-01
coleção:Upsala Journal of Medical Sciences
Assuntos:
neuroendocrine carcinoma
neuroendocrine neoplasm
braf-mutation
braf-inhibitors
targeted therapy
small-molecule targeted drug
Acesso em linha:https://ujms.net/index.php/ujms/article/view/10660/17118
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